Man.. I've seen like 10 posts in the last few days about inserting patches.
You need to use xkas (an assembler) to insert them into your ROM. A guide for that can be found at the bottom of this post. If you don't understand, then you can use xkas GUI, it's a GUI app with big buttons for loading files and patching. Download can be found here.
Don't forget to add freespace to the patches, otherwise bad things can happen.