Well, that really depends on both the song and the sample. Most sampled songs tune the samples with ADSR, so if you use a different sample, it may sound quite bad. Now, this won't necessarily happen, but it could. On the other hand, a lot of samples, when used, are out of tune, so if you're creating a new bank for an unsampled song, you'll most likely have to tune it until it sounds right. Hope I helped.
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